Endocrine Abstracts

There are increasing evidences that leptin, a protein secreted by adipose tissue, may be an important factor contributing to the development of atherosclerosis. In this study, the relationship between plasma leptin levels and markers of inflammation and endothelial activation was investigated in 214 obese nondiabetic children and adolescents. Fasting levels of leptin, C-reactive protein (CRP), fibrinogen (FB), interleukin-6 (IL-6), interleukin-1β (IL-1β), intercellul...

Disorders of bone mineralization observed in women with ovarian insufficiency are unlikely a simple function of decreased concentration of oestrogens. Published evidence suggests that adipose tissue is a central component within the complex system of metabolic and hormonal interactions responsible for adequate mineralization of the bone. However, to the best of our knowledge, the composite effects of specific substances synthesized within adipose tissue from various anatomical...

Available evidence suggests that unfavorable changes in the distribution of body fat resulting from hormonal imbalance associated with ovarian insufficiency may exert detrimental effects on bone mineral density (BMD). The aim of this study was to verify if densitometrically determined volumes of visceral (VAT), female (FAT) and android (AAT) adipose tissue influence BMD in women with menstrual disorders, and if these relationships are modulated by endocrine factors. The study ...